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[Observance of antifibrotic treatment in the French OPALE support program for patients with pulmonary fibrosis]
S Jouneau1, G Prévot2, A Constantin3
1Service de Pneumologie, Centre de référence constitutif pour les maladies rares pulmonaires, Hôpital Pontchaillou, IRSET UMR 1085, Université de Rennes, CHU de Rennes, 2, rue Henri Le Guilloux, 35033 Rennes, France.
Introduction:
The OPALE program has been designed to bolster observance of antifibrotic treatments in patients with diffuse interstitial lung disease (ILD). The effectiveness of these treatments depends largely on therapeutic adherence, which is often vitiated by side effects. The objective of this study was to describe the evolution and maintenance of treatment observance among participants in the OPALE program.
Methods:
A retrospective analysis was carried out regarding patients in the OPALE program over the course of nine months. Observance was measured using the Girerd self-administered questionnaire, and side effects were collected based on the participants' declarations.
Results:
Among the 976 participants in the program, 319 definitively withdrew, including 187 due to treatment discontinuation; satisfactory treatment observance was noted in 67.4%. Notwithstanding distinct side effects, no difference regarding observance was noted among patients on nintedanib as opposed to pirfenidone. No single factor was associated with treatment observance.
Conclusion:
The OPALE program assessed observance of antifibrotic treatments among patients with ILD. Additional studies ensuring prospective assessment with more adapted tools are called for, the objectives being to confirm these results and to identify factors potentially impacting observance.
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