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Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
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Astrocyte-neurone crosstalk mediates dexmedetomidine sedation

Beverley A Orser1, Connor T A Brenna2, Mervyn Maze3

  • 1Perioperative Brain Health Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Anesthesiology & Pain Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Anesthesiology and Pain Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

British Journal of Anaesthesia
|April 30, 2026
PubMed
Abstract

Keywords:
GABA(A) receptorsastrocytesbestrophin-1 channelsdexmedetomidine-induced sedationextrasynaptic receptorglutamatergic neuronespresynaptic receptorα(2)A-adrenergic receptor

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