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Haplotype-resolved chromosome-level genome assembly of Schizothorax davidi
Chuanshuai Xie1, Yuanhang Li1, Yan Zhou1
1MOE Key Laboratory of Freshwater Fish Reproduction and Development, College of Fisheries, School of Life Sciences, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Southwest University, Chongqing, 400715, China.
None:
Schizothorax davidi, a cold-water fish endemic to the Qinghai-Tibetan Plateau (QTP), represents an important economic resource in the upper Yangtze River. Regarded as a promising model for studying high-altitude adaptation and polyploidization, this species has still lacked a reference genome. Here, we report a haplotype-resolved, chromosome-scale genome of S.davidi (4n = 98), generated by integrating PacBio HiFi, Oxford Nanopore ultralong, and Hi-C sequencing data. The assembly spans 3.7 Gb across 98 chromosomes with a scaffold N50 of 36.93 Mb, includes 98,079 annotated protein-coding genes, and reveals large-scale regions of lost heterozygosity across 11 chromosomes. This haplotype-resolved genomic resource will advance the study of vertebrate polyploidy and adaptive evolution.
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