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Updated: May 2, 2026

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
Published on: April 27, 2017
The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell
Tanel Punga1, Mårten Larsson2,3, Endrina Mujica4
1Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. tanel.punga@imbim.uu.se.
Abstract:
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf87 as a previously uncharacterized functional subunit of the MIER corepressor complex that mediates HDAC1 and MIER1 protein interactions. Homozygous knockout of C16orf87 alters chromatin accessibility and reduces cell migration in human cells, and impairs embryonic development of zebrafish. Based on these findings, we propose renaming C16orf87 as HDAC Interacting Protein (HDIP) to reflect its newly revealed function.
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