Related Experiment Video
Updated: May 2, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Genome-wide cross-trait analysis reveals shared genetic architecture between inflammatory bowel disease and
Wulong Li1, Guang Liu2, Dan Wei3
1Department of Gastrointestinal Surgery, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, Nanchang, China. wywy20230722@163.com.
Abstract:
Patients with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) are clinically closely related. They suffer from comorbidities, possibly attributed to a shared genetic structure. By utilizing the genome-wide association study (GWAS) data of IBD and AS as the study object, the overall and local genetic associations were first assessed by employing the linkage disequilibrium score regression (LDSC), GNOVA, and high-definition likelihood (HDL). Subsequently, SUPERGNOVA was employed to identify region-specific genetic signals across chromosomes; finally, conditional and conjunctional false discovery rate (cond/conjFDR) and PLACO approaches were applied to quantify genetic overlap and identify shared susceptibility loci between the two disorders. Genome-wide analyses revealed a significant positive genetic correlation between IBD, including its subtypes, and AS. Regional-level analysis further indicated that the two phenotypes share localized genetic architecture across multiple chromosomal segments. ConjFDR assessment confirmed substantial genetic overlap and identified a set of key shared genetic variants and enriched pathways potentially involved in the pathogenesis of both diseases. The present study provides genetic evidence for IBD and AS comorbidity, which may enhance our understanding of the physiopathological aspects of the two diseases.
More Related Videos
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Inflammatory Bowel Disease III: Crohn's Disease
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations

