Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

395
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
395
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

354
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
354
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
367
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

861
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
861
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

2.1K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
2.1K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

382
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
382

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does Early Opioid Use for Relief of Acute Abdominal Pain Increase Use of Abdominal CT or Prolong Emergency Department Length of Stay?

Emergency medicine international·2026
Same author

Feasibility of administering the Patient-Reported Outcome Measure for Older People living with frailty receiving Acute Care (PROM-OPAC) in older people with cognitive impairment.

Emergency medicine journal : EMJ·2026
Same author

Trauma as a critical condition in the very old: assessment, care pathways and outcome differences.

European geriatric medicine·2026
Same author

What does frailty mean to older, racialised minority migrants living in the UK? A qualitative exploration of meaning and interpretation.

Age and ageing·2026
Same author

Motivating Factors for Participating in the Geriatric Emergency Department Guidelines 2.0.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2026
Same author

A Systematic Review Evaluating Pain Assessment Strategies for Patients With Dementia in the Emergency Department: The Geriatric ED Guidelines 2.0.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2026

Related Experiment Video

Updated: May 2, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

22.0K

Geriatric critical care assessment: key considerations.

James D van Oppen1, Ben Bloom2,3, Simon Conroy4,5

  • 1Centre for Urgent and Emergency Care Research, University of Sheffield, Sheffield, S1 4DA, UK. james.vanoppen@nhs.net.

European Geriatric Medicine
|April 30, 2026
PubMed
Summary

Geriatric critical care must shift focus from survival to person-centered outcomes for frail older adults. Implementing frailty-attuned care ensures interventions align with patient values and desired results.

Keywords:
Comprehensive geriatric assessmentCritical illnessFrailtyPerson-centred care

More Related Videos

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

9.8K

Related Experiment Videos

Last Updated: May 2, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

22.0K
Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

9.8K

Area of Science:

  • Geriatric Medicine
  • Critical Care Medicine
  • Public Health

Background:

  • Frailty, multimorbidity, and altered physiology significantly impact older adults in critical care.
  • Frailty is a more potent predictor of adverse outcomes than age alone.
  • Current geriatric critical care models often lack alignment with patient-centered goals.

Purpose of the Study:

  • To advocate for a paradigm shift in geriatric critical care towards person-centered, frailty-attuned approaches.
  • To emphasize aligning critical care structures and processes with outcomes valued by older adults with frailty.
  • To propose practical frameworks for implementing frailty-attuned care.

Main Methods:

  • This is a narrative review of the current literature and clinical practices in geriatric critical care.
  • It examines the role of frailty in predicting outcomes and influencing management decisions.
  • It reviews the ABCDE-Frailty framework and the 5Ms (Mind, Mobility, Medications, Multicomplexity, Matters most) for assessment.

Main Results:

  • Frailty screening alone is insufficient without changes in clinical approach.
  • The ABCDE-Frailty framework and 5Ms offer a structured method for frailty-attuned assessment.
  • Person-centered decision-making, based on shared values and goals, is crucial for proportionate treatment.

Conclusions:

  • A paradigm shift from survival-centered to person-centered care is essential in geriatric critical care.
  • Care should prioritize dignity, function, and patient-chosen outcomes, avoiding non-beneficial interventions.
  • Frailty-attuned geriatric critical care enhances the quality of life and aligns with the values of older adults.