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Related Experiment Video

Updated: May 2, 2026

Measuring Gene Expression in Bombarded Barley Aleurone Layers with Increased Throughput

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Published on: March 30, 2018

SOT2/Growth-Regulating Factor 3 Modulates Salt Tolerance by Regulating Gibberellin-DELLA Signalling.

Quang Tri Le^1,2, Hai An Truong³, Thi To Trinh Nguyen¹

¹Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.

Plant, Cell & Environment

|May 1, 2026

Summary

A new Arabidopsis mutant, salt overly tolerant 2 (sot2), reveals that AtGRF3 negatively regulates salt tolerance. Loss of AtGRF3 enhances plant growth and improves salt homeostasis by modulating gibberellin signaling under salt stress.

Keywords:

DELLA GA Growth‐regulating factor 3 arabidopsis plant salt tolerance

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Area of Science:

Plant Biology
Molecular Genetics
Stress Physiology

Background:

Salinity is a major abiotic stress limiting crop productivity worldwide.
Plant salt tolerance involves a complex interplay between stress defense mechanisms and growth regulation.

Purpose of the Study:

To identify genetic factors regulating plant salt tolerance.
To elucidate the molecular mechanisms underlying salt stress response and growth suppression.

Main Methods:

Forward genetic screen for salt-tolerant mutants in Arabidopsis.
Next-generation sequencing for mutant identification.
Genetic and functional analyses of the identified gene (AtGRF3).

Main Results:

A novel salt-tolerant mutant, sot2, was identified, with SOT2 encoding AtGRF3, a negative regulator of salt tolerance.
sot2 mutants showed enhanced growth, reduced sodium accumulation, and improved ionic homeostasis under salt stress.
AtGRF3 promotes gibberellin (GA) catabolism via GA2ox, leading to DELLA accumulation and growth inhibition; sot2 mutants exhibit reduced GA2ox expression and DELLA accumulation, alleviating growth suppression.

Conclusions:

AtGRF3 is a key negative regulator of salt tolerance in Arabidopsis.
AtGRF3 acts by modulating GA-DELLA signaling pathway under salt stress.
Targeting AtGRF3 offers a potential strategy for enhancing plant salt tolerance and crop improvement in saline environments.