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Mesenchymal Stem cell therapy with GHRH receptor analog resolves post-stroke vasogenic edema via modulating AQP4 and

Aishika Datta1, Bijoyani Ghosh1, Anita Kumari1

  • 1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, 382355, India.

Journal of Translational Medicine
|May 1, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
AquaporinsGrowth-hormone releasing hormone receptor analogsIschemic strokeMesenchymal stem cellsMitochondria-endoplasmic reticulum crosstalkVasogenic edema

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Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
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