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Published on: October 16, 2016
Spatial Confinement-Engineered Heteronuclear Diatomic Nanozymes for Modulation of Immune Homeostasis in Rheumatoid
Minke Wu1, Hongyang Li1, Pengcheng Wang1
1Suzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory For Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, China.
This study introduces novel heteronuclear diatomic nanozymes (HDNs) that effectively scavenge reactive oxygen species (ROS) and reprogram macrophages, offering a new therapeutic strategy for rheumatoid arthritis (RA). HDNs demonstrate significant anti-inflammatory effects, promoting joint health.
Area of Science:
- Biomedical Engineering
- Materials Science
- Immunology
Background:
- Rheumatoid arthritis (RA) progression involves M1 macrophage inflammation and reactive oxygen species (ROS) accumulation.
- Existing heteronuclear diatomic catalysts for RA lack precise control over interatomic synergy and multi-active site regulation.
Purpose of the Study:
- To engineer heteronuclear diatomic nanozymes (HDNs) using a spatial confinement strategy for dual-pathway RA therapy.
- To investigate the synergistic effects of Fe and Co sites within a nitrogen-coordinated carbon matrix for enhanced ROS scavenging and anti-inflammatory activity.
Main Methods:
- Spatial confinement strategy to create asymmetric Fe-Co configurations in a nitrogen-coordinated carbon matrix.
- Investigated spin-state and d-band center alignment for optimized enzymatic ROS scavenging.
- Evaluated HDN efficacy in modulating macrophage polarization and immune pathways via transcriptome sequencing.
Main Results:
- Engineered HDNs exhibited significantly enhanced SOD-like (3.66-fold) and CAT-like (3.21-fold) activities compared to monoatomic controls.
- HDNs promoted M2 macrophage polarization, creating an anti-inflammatory environment and reversing RA.
- Transcriptome analysis confirmed HDN-mediated immune homeostasis, inhibition of IL-17 and TNF pathways, and chondrocyte recovery.
Conclusions:
- Spatial confinement of heteronuclear sites in HDNs is crucial for synergistic catalytic activity and therapeutic efficacy in RA.
- HDNs represent a transformative platform for simultaneously remodeling redox and immune homeostasis in RA.
- This approach offers a promising strategy for developing advanced nanozyme therapeutics for inflammatory diseases.
