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Published on: May 2, 2013
Case Report: Lung transplant recipient with bullous pemphigoid and antibody-mediated rejection: an overlapping
Sandrine Hanna1, Daniel Gutteridge1, Christiane Machado2
1Pulmonary, Critical Care & Lung Transplant, Indiana University Health University Hospital, Indianapolis, IN, United States.
Abstract:
We present what is, to our knowledge, the first reported case of concurrent bullous pemphigoid (BP) and antibody-mediated rejection (AMR) in a lung transplant patient. Similar associations have been described in other solid organ transplant settings, most notably in renal transplantation, where explantation of the allograft has frequently been followed by resolution of the skin disease. These observations suggest a broader potential connection between autoimmune blistering disorders and allograft rejection mechanisms, especially as emerging evidence highlights the role of non-HLA antibodies. A comprehensive review of previously reported cases of BP in solid organ transplant recipients is therefore warranted to place this case in context and to assess its significance within the existing literature.
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