Related Experiment Video
Updated: May 2, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
Respiratory ventilation modes in selective ophthalmic arterial chemotherapy for pediatric retinoblastoma under
Yuxing Wang1, Xiang Dong1, Weiling Gao1
1Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objective:
To determine the optimal ventilation strategy for pediatric patients with retinoblastoma undergoing selective ophthalmic arterial chemotherapy (SOAC) by comparing the intraoperative effects of volume-controlled (VCV), pressure-controlled (PCV), and pressure-controlled volume-guaranteed (PCV-VG) ventilation.
Methods:
105 children (aged 1.5-5 years) undergoing SOAC were assigned to three groups: VCV (n = 33), PCV (n = 37), and PCV-VG (n = 35). Hemodynamics, airway pressures, end-expiratory carbon dioxide (EtCO2), arterial blood gases, and clinical complications were recorded and analyzed.
Results:
Postoperatively, the peak airway pressure in Group V was significantly higher than those in Group P and Group G. The EtCO2 of Group P was closer to normal values than that of the other two groups during surgery p < 0.05. Blood gas results at the three-time points showed that pH and HCO3 - values of Group P were closer to normal than those of the other two groups immediately after the operation and 5 minutes after the end of angiography, respectively p < 0.05. No significant differences of other indicators were found among the three groups.
Conclusion:
Altogether, compared with the VCV, both PCV and PCV-VG modes produced beneficial lower peak airway pressures during SOAC, thus conducing to prevent mechanical ventilation lung injury.
More Related Videos
05:43Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow
Published on: January 13, 2017
07:43Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
Published on: August 5, 2021
Related Concept Videos
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Cardiopulmonary Resuscitation II: ACLS Airway Management
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...