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Proteomic Profiling of Macrophages by 2D Electrophoresis
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Macrophages in psoriasis: a bibliometric analysis of research trends, knowledge gaps, and future directions
Hongda Yu1, Yifei Wang2,3, Qiuchen Huang3
1Department of Dermatology, China National Center for Integrated Traditional Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing, China.
Objective:
To systematically analyze the research landscape, knowledge structure, and evolution hotspots in macrophages and psoriasis research over the past decade through bibliometric analysis, providing guidance for mechanistic investigation and therapeutic strategies.
Methods:
Literature published between January 2015 and December 2024 was retrieved from the Web of Science database and Scopus. The softwares CiteSpace, VOSviewer, Scimago Graphica, and Excel were employed for bibliometric analysis, including co-occurrence networks, clustering analysis, and keyword evolution analysis.
Results:
A total of 2012 articles were identified from 2015 to 2024, showing an upward trend first and then slightly decreased. China and the United States were the leading contributors, while international collaboration formed four major clusters. Core journals such as Frontiers in Immunology and Journal of Immunology played pivotal roles in knowledge dissemination. Research hotspots evolved from fundamental inflammatory mechanisms to targeted biologic therapies, highlighting a growing emphasis on precision medicine and the immunopathogenesis of psoriasis.
Conclusion:
Macrophage and psoriasis-related research represents a rapidly evolving interdisciplinary field transitioning from isolated pathological studies to comprehensive research integrating advanced technologies with clinical applications. While substantial progress has been achieved in exploring macrophage roles in psoriasis pathogenesis, significant gaps remain between laboratory discoveries and clinical translation. Future research should prioritize international collaboration, application studies, and precision therapeutic strategies targeting macrophage-mediated pathways.
