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Updated: May 2, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Total Syntheses of (+)-Hyperbeanols A-C, (+)-Hyperpatulol A, and (-)-Hypercohone G, as Well as Structure Revision of
Xiao Liu1, Tianhao Ma1, Yu Bai1,2
1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Chemical Biology Center, Peking University, 38 Xueyuan Road, Beijing 100191, China.
Abstract:
Hyperbeanols A-C, hyperpatulol A, and hypercohone G belong to spirocyclic polycyclic polyprenylated acylphloroglucinols (PPAPs). These natural products share the same unusual 6/6/5 spirocyclic skeleton and possess five stereocenters. The total syntheses of hyperbeanols A-C, hyperpatulol A, and hypercohone G have been accomplished. Among them, hyperbeanols B/C, hyperpatulol A, and hypercohone G were synthesized for the first time. The concise synthesis featured a Knoevenagel condensation to link two fragments and a Mn-(III)-mediated radical cyclization to construct the 6/6/5 spirocyclic skeleton. Besides, we also revised the structures of hyperpatulol A and hyperbeanol B.
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