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Related Experiment Videos

The basement membrane exfoliation syndrome.

R C Eagle, R L Font, B S Fine

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |March 1, 1979
    PubMed
    Summary

    Pseudoexfoliation of the lens capsule involves abnormal basement membrane material production by ocular cells. This exfoliative material is found throughout the anterior segment and even in orbital blood vessels, suggesting a systemic condition.

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    Clinicopathologic reports, case reports, and small case series: progressive growth of benign adenoma of the pigment epithelium of the ciliary body.

    Archives of ophthalmology (Chicago, Ill. : 1960)·2001

    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Pathology

    Background:

    • Pseudoexfoliation of the lens capsule is suspected to involve abnormal basement membrane material production.
    • Previous studies indicated exfoliative material could originate from cells across the anterior eye segment.

    Observation:

    • Abundant exfoliative material was observed on ciliary and iridic epithelia.
    • The lens epithelial cells were necrotic, with no exfoliative material on the lens surface.
    • Exfoliative material was found near abnormal endothelial basement membrane in the iris stroma.

    Findings:

    • Exfoliative material, a filamentous basement membrane with 500-Å periodicity, was identified in ocular tissues and a posterior ciliary artery.
    • Evidence suggests local production of exfoliative material within the iris.
    • The exfoliative process extends beyond ocular tissues to orbital vasculature.

    Implications:

    • The findings support the hypothesis that pseudoexfoliation involves abnormal basement membrane production.
    • The presence of material in the ciliary artery suggests the condition may not be limited to the eye.
    • The term "basement membrane exfoliation syndrome" is proposed to encompass these observations.

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