C(sp3)-H Carboxylation via Carbene/Photoredox Cooperative Catalysis
Cullen R Schull1, Jing Cao1, Sophia R Mitton-Fry1
1Department of Chemistry, Northwestern University 2145 Sheridan Road, Evanston, IL 60208.
Abstract:
C(sp3)-H bond functionalization is a powerful strategy for the synthesis of organic compounds due to their abundance in simple starting materials. Photoredox catalysis has led to a diverse array of enabling C(sp3)-H activation strategies; however, a general platform for the direct functionalization of C(sp3)-H to carboxylic acid derivatives remains elusive. Disclosed herein is the development of a cooperative NHC/photoredox-catalyzed C(sp3)-H esterification transformation. This method enables access to benzylic, α-heteroatom, and formal β-esterification products in good to excellent yields under mild reaction conditions.
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