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Pediatric Rotavirus A Infection Among 337,019 Participants Within Asia: A Pan-Asian Systematic Review and
Ali A Rabaan1,2,3, Bello E Kizito4, Abdulsalam Alawfi5
1Molecular and Agnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Saudi Arabia, jhah.com.
Journal of Tropical Medicine
|May 1, 2026
Summary
Rotavirus A infections are common in Asian children, with about a quarter testing positive. This highlights the critical need for widespread rotavirus A vaccination programs across the region.
Area of Science:
- Pediatric Infectious Diseases
- Virology
- Public Health Epidemiology
Background:
- Rotavirus A is a primary cause of severe gastroenteritis in children under five in Asia.
- Existing vaccination programs have not fully curbed the incidence of rotavirus A infections.
- This study addresses the need for updated data on rotavirus A prevalence in Asian pediatric populations.
Purpose of the Study:
- To systematically review and meta-analyze the available evidence on rotavirus A detection rates.
- To determine the pooled proportion of rotavirus A positivity among children tested in Asia.
- To identify factors influencing rotavirus A detection rates across different Asian settings.
Main Methods:
- A systematic review and meta-analysis of 111 studies involving 337,019 children aged five and under.
- Random-effects meta-analysis was employed to calculate pooled rotavirus A positivity.
- Inter-study heterogeneity was quantified using the I-squared statistic.
Main Results:
- The overall pooled proportion of rotavirus A positivity was 24.7% (95% CI: 22.4%-27.1%).
- Significant heterogeneity (I-squared = 99.42%) was observed, indicating variations in diagnostic methods and study populations.
- Higher detection rates were noted in Saudi Arabia (49.3%), Iran (35.2%), Malaysia (33.0%), and India (29.4%).
- ELISA-based diagnostics and cross-sectional study designs were associated with increased detection rates.
Conclusions:
- Nearly a quarter of tested children in Asia are positive for rotavirus A.
- Significant variations in rotavirus A positivity underscore the need for tailored public health interventions.
- The findings emphasize the importance of implementing and expanding routine rotavirus A vaccination programs throughout Asia.
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