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Updated: May 2, 2026
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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
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Helicobacter pylori Eradication Using Empirical Therapy in Symptomatic Pediatric Patients: A Multicenter Real-World
José Fernando Vera Chamorro1,2,3, Carolina Zambrano4,5,1, Constanza Camargo6,7
1School of Medicine, Universidad de los Andes, Bogotá, COL.
Cureus
|May 1, 2026
Summary
Optimizing amoxicillin dosing and adherence are crucial for successful Helicobacter pylori eradication in Colombian children. Achieving adequate weight-based dosing significantly improves treatment success rates, reducing gastric cancer risk.
Area of Science:
- Pediatric Infectious Diseases
- Gastroenterology
- Pharmacology
Background:
- Helicobacter pylori (Hp) infection is a significant public health concern in Colombia, contributing to high gastric cancer rates.
- Effective Hp eradication in children is essential for preventing long-term complications, including gastric cancer.
- Optimizing amoxicillin dosage and ensuring patient adherence are modifiable factors to improve treatment outcomes.
Purpose of the Study:
- To evaluate real-world Helicobacter pylori eradication rates in Colombian children.
- To identify independent predictors of successful Hp treatment in pediatric patients.
- To assess the impact of amoxicillin dosing and adherence on eradication success.
Main Methods:
- Secondary analysis of the multicenter "LatamPed-Hp" REDCap registry.
- Inclusion of treatment-naïve children with confirmed Hp infection across 26 centers in 14 Colombian cities.
- Analysis of demographic data, clinical symptoms, and pharmacological regimens, with eradication confirmed post-treatment via non-invasive methods.
- Bivariate and multivariable logistic regression models used to identify predictors of treatment success.
Main Results:
- Overall Hp eradication rate was 81.8% in 330 included children.
- Adequate weight-based amoxicillin dosing (aOR 2.76) and high treatment adherence (aOR 48.99) were significant independent predictors of success.
- Absence of non-gastrointestinal comorbidities was associated with higher eradication rates (aOR 0.21 for failure).
Conclusions:
- Helicobacter pylori eradication rates in Colombian children fall below international targets.
- Pharmacological precision, particularly adequate weight-based amoxicillin dosing, is critical for treatment success.
- Improving adherence to weight-based protocols and enhancing treatment compliance are essential strategies to optimize Hp eradication and mitigate gastric cancer risk.
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