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  1. Home
  3. Absolute Temperature Mapping Using Chiral Terbium Parashift Complexes For Mri Thermometry.
  1. Home
  3. Absolute Temperature Mapping Using Chiral Terbium Parashift Complexes For Mri Thermometry.

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Absolute Temperature Mapping Using Chiral Terbium Parashift Complexes for MRI Thermometry.

Carlson Alexander1, Huishan Li1, Peter Harvey2,3

  • 1Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR 999077, China.

Chemical & Biomedical Imaging
|May 1, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

This study introduces Parashift molecular imaging for MRI-based temperature mapping. This noninvasive method uses lanthanide complexes to achieve precise, calibration-free temperature readings with high resolution.

Keywords:
Parashift agentschiral lanthanide complexesmacrocyclic chemistrymagnetic resonance spectroscopic imagingmolecular imagingparamagnetic NMRtemperature responsive probes

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Area of Science:

  • Molecular Imaging
  • Magnetic Resonance Imaging (MRI)
  • Chemical Physics

Background:

  • Accurate temperature mapping is crucial for understanding biological processes.
  • Current MRI thermometry methods often require external calibration or lack precision.
  • Molecular imaging probes offer potential for enhanced sensitivity and specificity.

Purpose of the Study:

  • To develop a noninvasive MRI approach for absolute temperature mapping using Parashift molecular imaging probes.
  • To evaluate the suitability of specific lanthanide complexes as temperature reporters.
  • To demonstrate the feasibility of high-resolution temperature mapping in phantom experiments.

Main Methods:

  • Utilized Parashift molecular imaging probes based on chiral lanthanide complexes.
  • Exploited chemical shift differences between CH2 SAP and CH3 TSAP resonances for temperature readout.
  • Performed variable-temperature NMR analyses to identify optimal reporter resonances.
  • Conducted phantom imaging experiments at 9.4 T.

    • Main Results:

    • Identified CH2 SAP and CH3 TSAP resonances as optimal reporters due to large hyperfine shifts and narrow line widths.
    • Observed high temperature coefficients (up to 0.46 ppm K⁻¹) for [DyL]⁻.
    • Achieved normalized coefficients up to 1.7 K⁻¹ for [TmL]⁻.
    • [TbL]⁻ showed the most promising temperature sensitivity.
    • Successfully mapped temperature variations with 0.1 K resolution in phantom studies.

    Conclusions:

    • Parashift molecular imaging provides a viable noninvasive method for absolute temperature mapping with MRI.
    • Lanthanide complexes, particularly [TbL]⁻, are effective for temperature-sensitive spectral imaging.
    • The developed technique offers high precision and eliminates the need for external calibration.