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Absolute Temperature Mapping Using Chiral Terbium Parashift Complexes for MRI Thermometry.

Carlson Alexander¹, Huishan Li¹, Peter Harvey^2,3

¹Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR 999077, China.

Chemical & Biomedical Imaging

|May 1, 2026

Summary

This summary is machine-generated.

This study introduces Parashift molecular imaging for MRI-based temperature mapping. This noninvasive method uses lanthanide complexes to achieve precise, calibration-free temperature readings with high resolution.

Keywords:

Parashift agents chiral lanthanide complexes macrocyclic chemistry magnetic resonance spectroscopic imaging molecular imaging paramagnetic NMR temperature responsive probes

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Area of Science:

Molecular Imaging
Magnetic Resonance Imaging (MRI)
Chemical Physics

Background:

Accurate temperature mapping is crucial for understanding biological processes.
Current MRI thermometry methods often require external calibration or lack precision.
Molecular imaging probes offer potential for enhanced sensitivity and specificity.

Purpose of the Study:

To develop a noninvasive MRI approach for absolute temperature mapping using Parashift molecular imaging probes.
To evaluate the suitability of specific lanthanide complexes as temperature reporters.
To demonstrate the feasibility of high-resolution temperature mapping in phantom experiments.

Main Methods:

Utilized Parashift molecular imaging probes based on chiral lanthanide complexes.
Exploited chemical shift differences between CH2 SAP and CH3 TSAP resonances for temperature readout.
Performed variable-temperature NMR analyses to identify optimal reporter resonances.
Conducted phantom imaging experiments at 9.4 T.

Main Results:

Identified CH2 SAP and CH3 TSAP resonances as optimal reporters due to large hyperfine shifts and narrow line widths.
Observed high temperature coefficients (up to 0.46 ppm K⁻¹) for [DyL]⁻.
Achieved normalized coefficients up to 1.7 K⁻¹ for [TmL]⁻.
[TbL]⁻ showed the most promising temperature sensitivity.
Successfully mapped temperature variations with 0.1 K resolution in phantom studies.

Conclusions:

Parashift molecular imaging provides a viable noninvasive method for absolute temperature mapping with MRI.
Lanthanide complexes, particularly [TbL]⁻, are effective for temperature-sensitive spectral imaging.
The developed technique offers high precision and eliminates the need for external calibration.