Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polygenic Traits01:18

Polygenic Traits

7.1K
7.1K
Polygenic Traits01:18

Polygenic Traits

58.4K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
58.4K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

973
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
973
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

121
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
121
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

890
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
890

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of a polygenic risk score to enhance early detection of coronary atherosclerosis.

American journal of preventive cardiology·2026
Same author

Genetic and clinical risk factors for recurrent events among patients with coronary artery disease.

American journal of preventive cardiology·2026
Same author

Body mass index threshold for obesity should be personalized based on polygenic score: Analysis of european and east asian biobanks.

American journal of preventive cardiology·2026
Same author

Performance of Cardiovascular Polygenic Risk Scores in Carotid Stenosis Identification.

medRxiv : the preprint server for health sciences·2026
Same author

Safety of migraine prophylaxis with calcitonin gene-related peptide monoclonal antibodies in comorbid chronic inflammatory central nervous system disease: A case series.

Headache·2026
Same author

Higher disease reactivation risk in women after fingolimod withdrawal.

Acta neuropathologica communications·2026

Related Experiment Video

Updated: May 2, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

1.2K

Evaluating Individual Level Performance of Polygenic Risk Scores Using Early Onset High Genetic Risk Coronary Artery

Shengxin Liang1,2, Min Seo Kim2,3, Yang Sui2,3,4

  • 1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Medrxiv : the Preprint Server for Health Sciences
|May 1, 2026
PubMed
Summary

Polygenic risk scores (PRSs) show poor individual prediction for coronary artery disease (CAD). A new benchmark cohort reveals PRSs capture less than a third of high-genetic-risk patients, highlighting the need for better clinical validation.

More Related Videos

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.4K
Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

221

Related Experiment Videos

Last Updated: May 2, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

1.2K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.4K
Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

221

Area of Science:

  • Cardiovascular Genetics
  • Precision Medicine
  • Genomic Risk Prediction

Background:

  • Population-level metrics for polygenic risk scores (PRSs) obscure individual risk prediction accuracy.
  • Clinical translation of PRSs is hindered by a lack of validation in diverse patient subgroups.

Purpose of the Study:

  • Introduce a novel "benchmark" cohort to assess individual-level PRS performance.
  • Evaluate the clinical readiness of 58 published coronary artery disease (CAD) PRSs.
  • Compare PRS performance against established non-genetic biomarkers.

Main Methods:

  • Defined a "benchmark" cohort of 1184 early-onset CAD patients (<55 years) with low clinical risk.
  • Assessed the proportion of benchmark patients captured by 58 published CAD PRSs.
  • Analyzed lipid profiles of benchmark patients not captured by any PRS.

Main Results:

  • A significant disconnection exists between population-level PRS performance and individual-level accuracy.
  • The proportion of benchmark patients captured by PRSs ranged from 10.8% to 33.1%.
  • The top-performing PRS was twice as effective as lipoprotein(a) in identifying high-risk individuals; uncaptured patients had healthier lipid profiles.

Conclusions:

  • The novel benchmark cohort provides a "ground truth" for evaluating PRS clinical utility.
  • Current PRSs demonstrate limited ability to identify individuals with high genetic predisposition to early CAD.
  • This framework is essential for validating the clinical readiness of PRSs.