Giant primary mediastinal well-differentiated liposarcoma with bilateral thoracic extension causing complete left...

Primary mediastinal liposarcomas are exceedingly rare mesenchymal tumors that can grow to a massive size before becoming symptomatic, often leading to diagnostic and therapeutic challenges. We present the case of a 45-year-old male with a giant, well-differentiated liposarcoma occupying the entire left hemithorax, anterior mediastinum and extending into the contralateral hemithorax, causing complete collapse of the left lung. The patient underwent a successful complete surgical resection via a single posterolateral thoracotomy, leading to an excellent postoperative outcome. This case highlights the importance of considering this rare entity in the differential diagnosis of large thoracic masses and underscores the feasibility and efficacy of complete surgical excision even for tumors of exceptional size.