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Related Experiment Video

Updated: May 2, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

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High-Risk Substance and Polysubstance Use Among Elective Surgery Patients: Prevalence and Risk Factors.

Xintong Ju1, Amelia C Mueller-Williams1, Ashley Kocher1

  • 1Addiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI.

Journal of the American College of Surgeons
|May 1, 2026
PubMed
Summary

Over a quarter of patients undergoing elective surgery report high-risk substance use, including cannabis and alcohol. Universal preoperative screening is recommended to identify at-risk individuals for better surgical outcomes.

Keywords:
alcohol usecannabis usenicotine usepolysubstance usepreoperative screeningsubstance use

Related Experiment Videos

Last Updated: May 2, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

22.5K

Area of Science:

  • Perioperative Medicine
  • Public Health
  • Addiction Medicine

Background:

  • Substance use is a modifiable risk factor impacting surgical outcomes.
  • Prevalence of substance use in preoperative patients using risk-specific thresholds is not well-defined.

Purpose of the Study:

  • To characterize the prevalence of high-risk substance use in a preoperative patient population.
  • To identify patient and surgical factors associated with high-risk substance use.

Main Methods:

  • Cross-sectional analysis of 2,688 adult patients undergoing elective surgery.
  • Validated self-report assessments for alcohol, nicotine, cannabis, and other drug use.
  • High-risk use defined by AUDIT-C scores ≥5 or weekly/daily use; polysubstance use defined as >1 high-risk substance.

Main Results:

  • 27.6% of patients reported high-risk substance use; 6.6% reported polysubstance use.
  • Cannabis (15.0%), alcohol (11.1%), and nicotine (8.5%) were most prevalent.
  • Younger age, male sex, poorer self-reported health, and neurosurgery service were associated with higher odds of high-risk use.

Conclusions:

  • High-risk substance use is prevalent in over 25% of elective surgical patients.
  • Findings support universal preoperative substance use screening.
  • Screening can identify at-risk patients for targeted risk mitigation and improved perioperative outcomes.