Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Synaptic transmission: ion concentration changes in the synaptic cleft.

D Attwell, J F Iles

Proceedings of the Royal Society of London. Series B, Biological Sciences

|November 30, 1979

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).

Neuroscience·2008

Same author

Glutamatergic signaling in the brain's white matter.

Neuroscience·2008

Same author

Neurotransmitter receptors in the life and death of oligodendrocytes.

Neuroscience·2006

Same author

Simple models of stimulation of neurones in the brain by electric fields.

Progress in biophysics and molecular biology·2004

Same author

Vestibular-evoked muscle responses in patients with spinal cord injury.

Brain : a journal of neurology·2004

Same author

Interaction of low frequency electric fields with the nervous system: the retina as a model system.

Radiation protection dosimetry·2003

Same journal

Studies on the mechanism of action of picrotoxinin and other convulsants at the crustacean muscle GABA receptor.

Proceedings of the Royal Society of London. Series B, Biological sciences·2015

Same journal

The dynamics of burrowing in Ensis (Bibalvia).

Proceedings of the Royal Society of London. Series B, Biological sciences·2014

Same journal

The release of vasopressin without oxytocin in response to haemorrhage.

Proceedings of the Royal Society of London. Series B, Biological sciences·2014

Same journal

Hypothalamic pathways for independent release of vasopressin and oxytocin.

Proceedings of the Royal Society of London. Series B, Biological sciences·2014

Same journal

Variation in the long-tailed field-mouse (Apodemus sylvaticus (L>)) in the Channel Islands.

Proceedings of the Royal Society of London. Series B, Biological sciences·2014

Same journal

The effect of undernutrition on the postnatal development of the brain and cord in pigs.

Proceedings of the Royal Society of London. Series B, Biological sciences·2014

See all related articles

Synaptic activity alters ion concentrations in the synaptic cleft, affecting neuronal signaling. This study predicts significant ion changes at the frog neuromuscular junction and cat Ia synapse, impacting synaptic current dynamics.

Area of Science:

Neuroscience
Computational Biology
Electrophysiology

Background:

Synaptic transmission involves ion flow across membranes.
Ion concentration changes in the synaptic cleft can influence synaptic current properties.

Purpose of the Study:

To predict ion concentration changes in the synaptic cleft during synaptic activity.
To investigate the impact of these changes on synaptic current time dependence and reversal potential.

Main Methods:

Utilized published experimental data for predictive modeling.
Calculated sodium and potassium concentration changes at the frog neuromuscular junction.
Assessed sodium depletion at the cat Ia synapse.

Main Results:

Related Experiment Videos

Predicted significant ion concentration changes at both studied synapses.
These changes contribute to the time-dependent nature of synaptic currents.
Identified near-complete sodium depletion at the cat Ia synapse, explaining experimental findings.

Conclusions:

Synaptic cleft ion concentration dynamics are crucial for understanding synaptic current behavior.
The predicted effects on reversal potential at the frog neuromuscular junction are likely undetectable.
Sodium depletion at the cat Ia synapse explains the observed independence of synaptic current magnitude from channel activation and membrane potential.