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Updated: May 3, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
Delayed Abdominal Pain Following Botox® Bladder Injection Mimics Exercise-InducedTransient Abdominal Pain: A Case
Jeffery D Molkentin1, Luis F Queme2, Jack Rubinstein3
1Division of Molecular Cardiovascular Biology, Department of Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Background:
Overactive bladder and associated incontinence are increasingly treated with onabotulinumtoxinA (Botox®) intradetrusor injections. An observed but poorly understood side effect is generalized abdominal pain that simulates cramps.
Case Report:
Here, we describe a patient with lower left quadrant abdominal pain beginning 16 days after treatment that worsened in severity over several days and persisted for an additional 5 weeks before abating over 3 more weeks. The unique pain symptoms mimicked the acute condition known as exercise-induced transient abdominal pain (ETAP), rendering the patient's exertion and supine position intolerant due to pain intensity.
Conclusions:
The hypothesis is that the Botox spread from bladder injection sites impacts the same ill-defined visceral-somatic abdominal neuronal-muscular circuitry underlying the ETAP phenomenon or complex regional pain syndromes.
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