Advancing the Science of Patient Input in Drug Research and Development

Area of Science:

• Patient-centered drug discovery and development
• Translational science
• Regulatory science

Background:

• Patient input is crucial for developing medicines that meet patient needs.
• Barriers hinder the systematic collection and use of patient data in drug R&D.
• Advancing the Science of Patient Input Action Collaborative addresses these implementation challenges.

Purpose of the Study:

• Identify and address key barriers to implementing patient input in drug R&D.
• Align drug discovery, development, and regulation with patient priorities.
• Promote practical paths for integrating patient perspectives into medical research and practice.

Main Methods:

• Multi-stakeholder engagement to gather diverse perspectives.
• Focus on three research priorities: patient experience, benefit-risk perspectives, and clinical trial integration.
• Leveraging existing guidances, strategies, and use-case lessons learned.

Main Results:

• Identified key barriers to the systematic integration of patient input.
• Defined research priorities to advance the science of patient input.
• Proposed a comprehensive framework for incorporating patient input throughout drug R&D.

Conclusions:

• Systematic patient input integration shifts R&D from ad-hoc applications to everyday practice.
• A comprehensive framework is essential for reimagining and enriching patient input in drug R&D.
• Enhanced patient input leads to medicines that better meet patient needs and improve disease management.