A highly biocompatible chip for continuous blood electrolyte detection based on hydrophilic surface modification
Haixia Yu1, Chengtao Xu1, Zhiguang Tan1
1State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, 300072, China.
Talanta
|May 1, 2026
Summary
A new continuous blood electrolyte monitoring chip for extracorporeal circulation (ECC) uses surface modification to prevent biofouling. This enhances patient safety by enabling reliable, long-term detection of potassium, sodium, and calcium levels.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Materials Science
Background:
- Real-time monitoring of blood electrolytes during extracorporeal circulation (ECC) is vital for patient safety.
- Traditional single-point detection methods are insufficient for continuous monitoring needs.
Purpose of the Study:
- To develop a continuous blood electrolyte detection chip for real-time monitoring during ECC.
- To address the challenge of biofouling (adhesion of proteins and cells) on sensors and microchannels.
Main Methods:
- Integrated a sensor array with a microchannel for continuous detection of potassium, sodium, and calcium.
- Applied chemical doping and surface modification to enhance antifouling properties.
- Optimized storage conditions to extend operational lifespan.
Main Results:
- Surface treatments significantly increased hydrophilicity, reducing protein and platelet adhesion.
- The modified chips maintained potentiometric sensor performance.
- Achieved robust antifouling performance and reliable long-term detection in flowing blood without signal degradation.
Conclusions:
- The developed continuous electrolyte detection chip is effective for real-time monitoring in ECC.
- The surface modification strategy provides a straightforward and robust solution to biofouling.
- The chip enables reliable, long-term blood electrolyte analysis, improving patient safety during ECC.
