Related Experiment Video
Updated: May 3, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
Epigenetic control of ion channels in cardiac fibrosis
Xian-Ming Tao1, Peng Liu1, Peng Zhao1
1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, PR China; Center for Scientific Research and Experiment, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, PR China.
Abstract:
Cardiac fibrosis is a pathological process characterized by excessive collagen deposition and abnormal proliferation of cardiac fibroblasts. This condition can lead to impaired cardiac function and ventricular remodeling. The development of cardiac fibrosis involves multiple mechanisms, and studies confirm that epigenetic mechanisms play a crucial part in cardiac fibrosis. Maintaining ion channel homeostasis is essential for optimal cardiac function; any imbalance can induce a range of cardiovascular diseases. However, there is little in the way of a systematic overview of the epigenetic regulation of ion channels contributing to cardiac fibrosis. This review systematically summarizes the epigenetic mechanisms underlying ion channel-mediated cardiac fibrosis and discusses potential interventions and biomarkers, along with the challenges in this rapidly evolving field.
Related Concept Videos
G-Protein Gated Ion Channels
Sensory...
Heart Failure Drugs: Inotropic Agents
Mechanically-gated Ion Channels
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

