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Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
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Sensitivity-improved nanozyme LFIA with optimized fluid control on centrifugal microfluidic platform.

Lei Wang1, Jiaxi Zhou2, Hao Chen1

  • 1Institute of Microfluidic Chip Development in Biomedical Engineering, School of Information Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.

Analytica Chimica Acta
|May 1, 2026
PubMed
Summary

This study introduces a centrifugal microfluidic platform to enhance nanozyme-based lateral flow immunoassay (LFIA) sensitivity. The automated system optimizes sample and reagent handling for improved point-of-care diagnosis.

Keywords:
Centrifugation microfluidicImage analysisNanozyme-based LFIAPneumatic siphon valvePoint-of-care testing

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Microfluidics

Background:

  • Nanozyme-based lateral flow immunoassays (LFIA) face sensitivity limitations due to manual operation.
  • Inflexible manual processes lead to issues like poor chromatography, inefficient reagent use, and suboptimal binding.

Purpose of the Study:

  • To develop an automated centrifugal microfluidic platform to enhance nanozyme-LFIA sensitivity.
  • To overcome limitations of manual LFIA through improved automation and reaction efficiency.

Main Methods:

  • Development of a centrifugal microfluidic platform with pneumatic siphon valves for automated sample and reagent control.
  • Implementation of strategies for sustained sample delivery and controlled reaction times via centrifugal force.
  • Optimization of chip design to minimize sample and reagent loss.

Main Results:

  • Achieved automated operation of the entire nanozyme-LFIA process.
  • Demonstrated improved detection sensitivity through optimized chromatography and reaction conditions.
  • Reduced sample and reagent loss within the microfluidic chip.

Conclusions:

  • The centrifugal microfluidic platform significantly enhances nanozyme-LFIA sensitivity and efficiency.
  • This automated approach offers a promising solution for improved point-of-care (POC) diagnostic applications.