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Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

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Therapeutic nanoparticles and targeted therapy.

Vihaa Sriee Maambulikavil Ganesan¹, Meethu Gunasekaran¹, Janani Jayakumar¹

¹Centre of Excellence in Biofilms, Department of Biotechnology, Rajalakshmi Engineering College, Autonomous, Thandalam, Chennai, Tamil Nadu, India.

Advances in Cancer Research

|May 1, 2026

Summary

Nanotechnology offers a revolutionary approach to skin cancer treatment, overcoming limitations of conventional therapies. Nanoparticle-based drug delivery systems promise targeted, effective, and safer interventions for dermatologic oncology.

Keywords:

Immunotherapy Liposomes Nanoparticles Precision oncology Skin cancer Targeted drug delivery Theranostics

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Area of Science:

Dermatologic Oncology
Nanomedicine
Biotechnology

Background:

Skin cancer is a major global health concern with limitations in current treatments like chemotherapy and immunotherapy.
Conventional therapies often cause systemic toxicity, drug resistance, and undesirable side effects.
Nanotechnology presents a novel strategy to address these challenges in skin cancer management.

Purpose of the Study:

To explore the potential of nanotechnology in enhancing skin cancer therapy.
To review various nanocarrier systems and their applications in treating skin malignancies.
To discuss the integration of diagnostic and therapeutic capabilities (theranostics) in nanomedicine for skin cancer.

Main Methods:

Review of diverse nanocarrier systems including liposomes, micelles, and metallic nanoparticles.
Investigation of nanoparticle properties like size, surface modification (e.g., PEGylation), and biocompatibility.
Analysis of functional modifications for targeted drug delivery and improved therapeutic efficacy.

Main Results:

Nanoparticles enable site-specific drug delivery, improved drug solubility, and prolonged circulation.
Various nanocarrier systems demonstrate enhanced skin penetration, controlled release, and drug retention.
Functionalized nanoparticles offer improved stability, immune evasion, and receptor-mediated targeting.

Conclusions:

Nanotechnology represents a paradigm shift in precision dermatologic oncology.
Nanoparticle-based therapeutics offer safer, more effective, and patient-friendly skin cancer interventions.
Advancements in nanomedicine hold significant promise for future skin cancer treatment strategies.