Related Experiment Video
Updated: May 3, 2026
09:58
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
3.3K
In memoriam: Irene Schulz 1941 - 2026
1School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF103AX, Wales, UK.
Cell Calcium
|May 1, 2026
Summary
Irene Schulz
Area of Science:
- Cellular Biology
- Physiology
- Biochemistry
Background:
- Pioneering research in calcium signaling pathways.
- Investigated intracellular calcium (Ca2+) regulation.
Purpose of the Study:
- To elucidate the role of inositol-1,4,5 trisphosphate (IP3) in calcium release.
- Identify the intracellular store responsible for IP3-mediated Ca2+ release.
Main Methods:
- Experimental investigation of calcium signaling mechanisms.
- Directly demonstrated IP3-induced Ca2+ release from intracellular stores.
Main Results:
- Showed that inositol-1,4,5 trisphosphate (IP3) releases Ca2+.
- Identified the endoplasmic reticulum (ER) as the primary intracellular Ca2+ store for IP3 signaling.
Conclusions:
- Established IP3 as a critical second messenger in signal transduction.
- Laid the foundation for the field of Ca2+ Signaling.
Related Concept Videos
01:17Irritable Bowel Syndrome I: Introduction
1.4K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.4K
01:17Schizophrenia
1.8K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.8K
01:23Irritable Bowel Syndrome
36
DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility...
36
01:23Wechsler's Contribution to Measures of Intelligence
2.9K
David Wechsler, a psychologist who worked with World War I veterans, developed a significant IQ test in 1939 called the Wechsler-Bellevue Intelligence Scale. This test was innovative because it combined several subtests that measured both verbal and nonverbal skills, reflecting Wechsler's belief that intelligence is a global capacity involving purposeful action, rational thinking, and effective interaction with the environment. This test later evolved into the Wechsler Adult Intelligence...
2.9K
01:21EPS and iPS Cells in Disease Research
3.2K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.2K
01:23International Nursing Organizations I
2.2K
International Nursing Organization (ICN) is a global union of national nurses' organizations. Individual nurses can be a part of ICN through member organizations. Each member organization strives to ensure quality nursing care, sound health policies, the advancement of nursing knowledge, respect for the profession, and a satisfied and competent nursing workforce.
ICN member organizations work to advance the field of nursing and healthcare via policies, partnerships, lobbying, professional...
ICN member organizations work to advance the field of nursing and healthcare via policies, partnerships, lobbying, professional...
2.2K