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Updated: May 3, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Halting neuron-fibroblast crosstalk disarms tumor and augments immunotherapy
Pinchao Fan1, Xiaofei Zhi2, Weici Laurence Liu3
1Department of Oncology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Abstract:
Innervation propels tumor progression through intricate mechanisms. Recently, Zhang et al. demonstrated that sensory neurons interact with cancer-associated fibroblasts via the calcitonin gene-related peptide (CGRP)-receptor activity-modifying protein 1 (RAMP1) axis to mediate immune exclusion in triple-negative breast cancer. Halting the neuron-fibroblast crosstalk via rimegepant holds promise for reorganizing the extracellular matrix and synergizing with cancer immunotherapy.
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