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Socio-Occupational Functioning after Subthalamic Deep Brain Stimulation in Parkinson's Disease.
Gabriele Imbalzano1,2, Elisa Montanaro3, Martina Giacchero4
1Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.
Movement Disorders Clinical Practice
|May 2, 2026
Summary
Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients shows satisfactory socio-occupational functioning. Individual factors like sex and GBA variants, not motor scores, influenced outcomes.
Area of Science:
- Neuroscience
- Neurosurgery
- Genetics
Background:
- Standard scales inadequately assess socio-occupational functioning in Parkinson's disease (PD) patients undergoing subthalamic nucleus deep brain stimulation (STN-DBS).
- Patient-reported outcomes are crucial for a holistic understanding of STN-DBS effectiveness.
Purpose of the Study:
- To characterize patient-reported socio-occupational functioning following STN-DBS.
- To identify clinical and demographic factors associated with socio-occupational functioning after STN-DBS.
Main Methods:
- A cohort of 34 PD patients was evaluated 9-18 months post-STN-DBS using a semi-structured interview.
- A composite socio-occupational functioning score (Q_mean) was calculated.
- Univariate screening and multivariate linear regression explored associations with clinical and demographic variables.
Main Results:
- The mean Q_mean score post-STN-DBS was 7.67 ± 0.86.
- Female sex was associated with higher socio-occupational functioning (P=0.039).
- Glucocerebrosidase (GBA) variants were associated with lower socio-occupational functioning (P=0.028).
Conclusions:
- Socio-occupational functioning is generally satisfactory after STN-DBS.
- Outcomes are influenced more by individual factors (sex, genetics) than traditional motor/neuropsychiatric measures.
- Incorporating socio-occupational assessments is recommended for comprehensive STN-DBS outcome evaluation.
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