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Updated: May 3, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Regulated Cell Death in Idiopathic Pulmonary Fibrosis
Xiaoyue Pan1, Liu Yang1, Man Zhao1
1State Key Laboratory of Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Organ Fibrosis, Pingyuan Lab, College of Life Science, Henan Normal University, Xinxiang, China.
Idiopathic pulmonary fibrosis involves multiple regulated cell death (RCD) pathways. Targeting these interconnected RCD processes offers a promising therapeutic strategy for treating this chronic lung disease.
Area of Science:
- Pulmonary Medicine
- Cell Biology
- Pathophysiology
Background:
- Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease.
- IPF pathogenesis involves epithelial injury, fibroblast activation, and tissue remodeling.
- Multiple regulated cell death (RCD) modalities are implicated in IPF.
Purpose of the Study:
- To review the role of various RCD modalities in IPF.
- To explore the interconnectedness and coordination of these RCD pathways.
- To highlight therapeutic opportunities targeting RCD in IPF.
Main Methods:
- Literature review of RCD pathways in IPF.
- Analysis of the crosstalk between different cell death modalities.
- Examination of therapeutic strategies targeting RCD.
Main Results:
- Apoptosis, autophagy, necrosis, ferroptosis, pyroptosis, and cuproptosis contribute to IPF.
- These RCD pathways are interconnected and coordinated.
- Targeting RCD offers potential therapeutic benefits.
Conclusions:
- RCD pathways are complex and interact in IPF pathogenesis.
- Targeting RCD, individually or in combination, may restore lung repair.
- A conceptual framework for coordinated RCD regulation could drive therapeutic innovation.
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