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Updated: May 4, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
A Triple-Stimuli-Responsive Photolabile Protecting Group Platform for Controlled Release
Jieyun Huang1,2, Guoshan Jiang1, Long Wang1,3
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.
Abstract:
Photolabile protecting groups (PPGs) enable spatiotemporal control of chemical and biological processes, yet multistimuli-regulated systems remain rare. Here we report a triple-stimuli platform integrating light, base, and acid to control PPG release. Photoirradiation of diarylethenes (DAEs) under basic conditions generates stable 9,10-dihydrophenanthrene (9,10-DHP) intermediates that activate hemiaminal ethers and undergo acid-promoted aromatization to release the alcohol group. Distinct fluorescence changes allow real-time monitoring in both organic and aqueous media.
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