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Updated: May 4, 2026
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
13.8K
Live vaccines in solid organ transplant recipients
Rebecca Sturgis1, Lara Danziger-Isakov2, Amy Feldman3
1Cincinnati Children's Hospital Medical Center, Department of Infectious Diseases.
Current Opinion in Infectious Diseases
|May 2, 2026
Summary
Live vaccines like MMR and varicella are safe and effective for select pediatric solid organ transplant (SOT) recipients, improving protection against vaccine-preventable infections. Further research is needed for adult SOT patients.
Area of Science:
- Immunology
- Transplant Medicine
- Vaccinology
Background:
- Vaccine-preventable infections (VPIs) pose significant risks to solid organ transplant (SOT) recipients.
- Many SOT candidates and recipients have suboptimal vaccination coverage.
- Optimizing vaccination strategies before and after transplantation is crucial due to declining herd immunity.
Purpose of the Study:
- To review current evidence and evolving recommendations for live vaccine administration in SOT candidates and recipients.
- To assess the safety and immunogenicity of live vaccines in this vulnerable population.
- To identify knowledge gaps and areas for future research.
Main Methods:
- Review of modern evidence and evolving recommendations.
- Analysis of accumulating data, primarily from pediatric liver and kidney SOT cohorts.
- Evaluation of multicenter experience with posttransplant live vaccination.
Main Results:
- Vaccination coverage at transplant remains suboptimal, but interventions can improve uptake.
- Posttransplant measles, mumps, rubella (MMR) and varicella (VAR) vaccination is supported by data in select pediatric SOT recipients.
- Updated guidance and clinical practice reflect findings for specific pediatric SOT populations.
Conclusions:
- Live vaccine administration appears feasible and beneficial in carefully selected pediatric SOT recipients.
- Live vaccines may reduce susceptibility to VPIs in this population.
- Further research is essential for adult SOT recipients, non-liver transplant groups, and other live vaccines to define safety, immunogenicity, and optimal timing.
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