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Updated: Jul 13, 2026

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[Chorioamnionitis and long-term neurodevelopment in preterm infants: What can we learn from the EPIPAGE-2 cohort

Fanny Salmon1, Mathilde Letouzey2, Emeline Maisonneuve3

  • 1Inserm, OPPaLE Team, INRAE, CRESS, Obstetric, Perinatal, and Pediatric Life course Epidemiology, université Paris-Cité, Sorbonne Paris-Nord, 75006 Paris, France; Département de gynécologie obstétrique, université Paris-Cité, hôpital Robert-Debré, AP-HP, Paris, France.

Gynecologie, Obstetrique, Fertilite & Senologie
|May 2, 2026
PubMed
Summary

Intrauterine inflammation from chorioamnionitis in premature infants did not significantly impact long-term neurodevelopmental outcomes at five years. Early clinical chorioamnionitis showed a link to cerebral palsy at two years, but this association did not persist.

Keywords:
Chorioamniotite clinique chorioamniotite histologiqueClinical chorioamnionitisEPIPAGE-2Histological chorioamnionitisInflammation intra-utérineIntrauterine inflammationNeurodevelopmentNeurodéveloppementPretermPrématurés

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