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Related Experiment Video

Updated: May 4, 2026

Preparation of DNA-crosslinked Polyacrylamide Hydrogels
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Published on: August 27, 2014

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Recent advances in DNA hydrogels for biomedical applications.

Jiaqi Liang1, Jianbin Shi1, Boyu Jing2

  • 1Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

International Journal of Pharmaceutics
|May 2, 2026
PubMed
Summary

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DNA hydrogels offer advanced biosensing and drug delivery by overcoming limitations of traditional materials. This review highlights their design, mechanisms, and applications in medicine.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Engineering

Background:

  • DNA hydrogels integrate programmable DNA into 3D networks, offering precise recognition and signal transduction.
  • They overcome limitations of conventional platforms like poor stability, matrix interference, and high cost.
  • DNA hydrogels are attractive for biomedicine due to their unique properties.

Purpose of the Study:

  • To systematically review recent advances in DNA hydrogels for biosensing and drug delivery.
  • To provide insights into synthesis routes, design principles, and mechanisms.
  • To discuss applications, challenges, and future directions in the field.

Main Methods:

  • Review of recent literature on DNA hydrogel synthesis and design.
  • Analysis of mechanisms underlying DNA hydrogel function in biosensing and drug delivery.
Keywords:
BiosensingDNA hydrogelDrug deliverySynthesis and design

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  • Categorization of applications in medical detection, disease treatment, and theranostics.

    • Main Results:

    • DNA hydrogels exhibit enhanced sensing performance and therapeutic potential through customized designs.
    • Key design principles include crosslinking density regulation and stability protection.
    • Applications span medical diagnostics, targeted therapies, and theranostic platforms.

    Conclusions:

    • DNA hydrogels represent a promising platform for advanced biomedical applications.
    • Further research is needed to address current challenges and facilitate translational applications.
    • This review serves as a reference for rational design and development of DNA hydrogel systems.