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Updated: May 4, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
Published on: December 5, 2025
Implementation of High-Flow Nasal Cannula and Noninvasive Ventilation During Pediatric Interfacility Transport:
Maya Gagliardi-Lacharite1, Robert Schultz2, Kendel Ridgeway3
1Division of Pediatric Critical Care Medicine, Children's Hospital of Michigan, Detroit, MI.
The introduction of high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) for pediatric transport did not significantly change intubation rates. However, these advanced respiratory support methods reduced the use of less effective oxygen delivery methods during transport.
Area of Science:
- Pediatric critical care medicine
- Respiratory support
- Emergency medicine
Background:
- Limited respiratory support options previously existed for young children during interfacility transport.
- High-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) have recently become available for pediatric transport.
- These advanced methods offer potential improvements in respiratory care for critically ill infants and toddlers.
Purpose of the Study:
- To evaluate the impact of implementing HFNC and NIV on interfacility transport for pediatric patients.
- To determine if HFNC and NIV decrease the rate of intubation in infants and toddlers before and after transport to a pediatric intensive care unit (PICU).
Main Methods:
- A retrospective chart review was conducted on children aged 30 days to 36 months with respiratory distress.
- Patients were analyzed in groups before (2014-2017) and after (2017-2019) the implementation of HFNC/NIV during transport.
- The primary outcome was the comparison of intubation rates before transport and within 48 hours of PICU admission.
Main Results:
- No statistically significant difference was found in intubation rates before PICU admission (44% vs. 36%) or within 48 hours of PICU admission (8% vs. 11%).
- Comorbidities did not significantly affect intubation rates.
- A significant decrease in the use of nasal cannula or face mask oxygen was observed after HFNC/NIV implementation (46% vs. 13%).
Conclusions:
- The introduction of HFNC/NIV during interfacility transport led to increased utilization of these advanced methods.
- No significant change in intubation rates was observed following the implementation of HFNC/NIV.
- The study highlights a shift towards more advanced respiratory support during pediatric transport.
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