The behaviour of transporting epithelial cells. I. Computer analysis of a basic model

We analyse the non-steady state behaviour of a computer model representing functional epithelial cells. The results show that a simple model of an epithelium, containing the essential ion transport asymmetries of the original Koefoed-Johnsen-Ussing model, predicts much of the observed behaviour of 'tight-type' epithelia under various well characterized experimental conditions.