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Updated: May 5, 2026
Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
Self-programmable DNA hydrogel films design and application in biosensors
Zishan Li1, Yunfeng Xiang2, Shuaifeng Ji3
1Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Military Medical Sciences Academy, Academy of Military Sciences, Tianjin, 300050, PR China; State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, PR China.
Abstract:
DNA hydrogels have a wide range of applications in biosensing owing to the programmability of DNA. Different crosslinking modes are used in the formation of DNA hydrogels such that the hydrogels have different microscopic morphologie. As a special type of DNA hydrogel, the DNA hydrogel film is a membrane hydrogel formed by layer assembly, extrusion, or application of a DNA hydrogel. Compared with DNA hydrogels, DNA hydrogel films require less DNA to fabricate, have faster response times, and show significant advantages in electrochemical sensing, photoresponsive patterning, and binding to other materials. This review focuses on the research progress in DNA hydrogel films over the past six years. In this paper, hydrogels are classified according to their morphology. DNA hydrogel films have been classified according to their cross-linking methods. The applications of DNA hydrogel films in biosensing, drug delivery, cell culture, and point-of-care testing are also described. Finally, future applications of DNA hydrogel films are discussed.
