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Structural optimization of benzophenanthridinone and benzophenanthridine Tyrosyl-DNA phosphodiesterase 1 inhibitors

De-Xuan Hu1, Yue-Wen Li2, Ao Chen2

  • 1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Chengdu Medical College, Chengdu, 610500, China.

European Journal of Medicinal Chemistry
|May 3, 2026
PubMed

Keywords:
BenzophenanthridineBenzophenanthridinoneCancer resistanceDNA damageRadiosensitivityTyrosyl-DNA phosphodiesterase

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