Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

74
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
74
Next-generation Sequencing03:00

Next-generation Sequencing

87.9K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
87.9K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

836
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
836
Genomics02:02

Genomics

35.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.5K
Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

779
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
779
RNA-seq03:21

RNA-seq

9.4K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interregional outbreak of <i>Salmonella Typhimurium</i> linked to fresh cheese: A case-case study guided by whole-genome sequencing (WGS), Portugal, March-June 2024.

Epidemiology and infection·2026
Same author

Genomic evolution and re-emergence of a multidrug-resistant <i>Clostridioides difficile</i> RT027 clone with reduced vancomycin susceptibility driving a prolonged hospital outbreak.

Emerging microbes & infections·2026
Same author

Genomic and phenotypic characterization of Enterococcus faecalis from broiler sternal bursitis: antimicrobial resistance and one health risks.

Veterinary research communications·2026
Same author

Rapid drug resistance prediction in positive <i>Mycobacterium tuberculosis</i> clinical samples using an extensive targeted next-generation sequencing panel.

Emerging microbes & infections·2026
Same author

Detection of dengue virus serotype 2 in local Aedes aegypti populations, Madeira Island, Portugal, 2025.

Parasites & vectors·2026
Same author

Detection of polycyclic aromatic hydrocarbons, microplastic presence and characterization of microbial communities in the soil of touristic zones at Alqueva's edges (Alentejo, Portugal).

Environmental science and pollution research international·2026

Related Experiment Video

Updated: May 5, 2026

Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings
10:26

Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings

Published on: August 18, 2023

5.9K

Genome Sequencing in Infectious Disease Outbreaks.

João Paulo Gomes1,2

  • 1Department of Infectious Diseases, Genomics and Bioinformatics Unit, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal. j.paulo.gomes@insa.min-saude.pt.

Advances in Experimental Medicine and Biology
|May 3, 2026
PubMed
Summary

Genome sequencing is vital for tracking infectious disease spread and evolution. This technology aids in identifying pathogen mutations and informs public health strategies for better outbreak control.

Keywords:
Antibiotic resistanceGenome sequencingInfectious diseasesInfectious sourceNext-generation sequencingOutbreakVaccineVirulence

More Related Videos

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
09:36

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Published on: July 2, 2016

16.9K
Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example
05:45

Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example

Published on: March 11, 2020

10.9K

Related Experiment Videos

Last Updated: May 5, 2026

Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings
10:26

Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings

Published on: August 18, 2023

5.9K
Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
09:36

Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Published on: July 2, 2016

16.9K
Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example
05:45

Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example

Published on: March 11, 2020

10.9K

Area of Science:

  • Microbiology
  • Epidemiology
  • Genomics

Background:

  • Genome sequencing is a critical tool for understanding and managing infectious disease outbreaks.
  • It enables precise tracking of pathogen spread and evolution by decoding genetic material.

Purpose of the Study:

  • To highlight the role of genome sequencing in infectious disease outbreak management.
  • To demonstrate its utility in tracing transmission, identifying mutations, and informing public health responses.

Main Methods:

  • Comparative analysis of pathogen genetic sequences from various sources.
  • Monitoring emergence of new variants and informing vaccine strategies.

Main Results:

  • Genome sequencing accurately traces disease transmission pathways and identifies outbreak sources.
  • It reveals mutations affecting transmissibility, virulence, and treatment resistance.
  • Crucial role demonstrated during COVID-19 pandemic for variant monitoring and vaccine strategies.

Conclusions:

  • Genome sequencing provides essential insights for targeted public health interventions.
  • Advancements in sequencing technology and decreasing costs will enhance future outbreak control and prevention strategies.