Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

438
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
438
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.5K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating inflammatory indices refine prognostic stratification and complication risk in pancreatic cancer following radical surgery.

Gland surgery·2026
Same author

Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A histone H2A and H2B point mutant library defines essential in vivo functions in Drosophila.

Cell reports·2026
Same author

A histone H2A and H2B point mutant library defines essential in vivo functions in Drosophila.

Cell reports·2025
Same author

Microstructure and Mechanical Properties of Friction Stir Welded the Novel Al-Mg-Zn-Si Alloy.

Materials (Basel, Switzerland)·2025
Same author

Investigation on Hot Deformation Behavior and Microstructural Evolution of Al-Mg-Zn Aluminum Alloy via Uniaxial Isothermal Hot Compression Tests.

Materials (Basel, Switzerland)·2025
Same journal

Denoising algorithm of Φ-OTDR systems based on adaptive fractional wavelet transform denoising.

Optics express·2026
Same journal

Millisecond photon-to-photon latency and high-speed volumetric projection system for optogenetics.

Optics express·2026
Same journal

Polarization-encoded coaxial structured light for high-precision 3D surface profilometry.

Optics express·2026
Same journal

Discrete freeform optical design based on collaborative optimization of point cloud and local normals.

Optics express·2026
Same journal

Ultrafast ghost imaging with 25 GHz speckle switching and wavelength-division multiplexing.

Optics express·2026
Same journal

Atomic vapor cells fabricated by femtosecond laser welding of standard-optical-quality glass.

Optics express·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Isotropic Light-Sheet Microscopy and Automated Cell Lineage Analyses to Catalogue Caenorhabditis elegans Embryogenesis with Subcellular Resolution
08:16

Isotropic Light-Sheet Microscopy and Automated Cell Lineage Analyses to Catalogue Caenorhabditis elegans Embryogenesis with Subcellular Resolution

Published on: June 6, 2019

9.6K

Acceleration and parallelization methods for the ISRS-EGN model.

Ruiyang Xia, Guanjun Gao, Daobin Wang

    Optics Express
    |May 4, 2026
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces an approximation for the four-wave mixing efficiency factor in optical fiber systems, significantly reducing computation time for nonlinear interference evaluation while maintaining high accuracy.

    More Related Videos

    Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
    10:45

    Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

    Published on: June 3, 2019

    6.4K
    Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients
    07:34

    Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients

    Published on: August 22, 2018

    7.6K

    Related Experiment Videos

    Last Updated: May 5, 2026

    Isotropic Light-Sheet Microscopy and Automated Cell Lineage Analyses to Catalogue Caenorhabditis elegans Embryogenesis with Subcellular Resolution
    08:16

    Isotropic Light-Sheet Microscopy and Automated Cell Lineage Analyses to Catalogue Caenorhabditis elegans Embryogenesis with Subcellular Resolution

    Published on: June 6, 2019

    9.6K
    Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
    10:45

    Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

    Published on: June 3, 2019

    6.4K
    Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients
    07:34

    Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients

    Published on: August 22, 2018

    7.6K

    Area of Science:

    • Optical Fiber Communications
    • Nonlinear Optics
    • Computational Physics

    Background:

    • The enhanced Gaussian noise (EGN) model accurately evaluates nonlinear interference (NLI) in optical fiber systems.
    • Inter-channel stimulated Raman scattering (ISRS) and four-wave mixing (FWM) contribute significantly to NLI.
    • High computational cost limits the practical application of physics-based NLI models.

    Purpose of the Study:

    • To address the computational bottleneck in the EGN model.
    • To develop an accurate and efficient approximation for the FWM efficiency factor.
    • To accelerate NLI evaluation in optical communication systems.

    Main Methods:

    • Identified oscillatory behavior of the FWM efficiency factor integrand as a computational bottleneck.
    • Developed a closed-form approximation for the FWM efficiency factor.
    • Implemented a parallel computation strategy exploiting independent integration domains.

    Main Results:

    • The proposed approximation yields a low mean absolute error (MAE) of ~0.0033 dB.
    • Achieved a reduction in computation time exceeding 99.6% compared to full integral evaluation.
    • Parallel computation further enhanced the efficiency of the NLI evaluation framework.

    Conclusions:

    • The approximated FWM efficiency factor enables faster and practical NLI assessment in optical systems.
    • The method maintains high accuracy under strong ISRS conditions.
    • Optimized parallel strategies significantly boost computational efficiency for EGN model applications.