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Association between C-reactive protein-triglyceride glucose index and overactive bladder: A population-based study
Yifan Shao1, Yangyang Mei2, Guoyang Zhang3,4
1Department of Urology, Traditional Chinese Medicine Hospital of Kunshan, Affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan, Jiangsu, China.
Medicine
|May 4, 2026
Summary
The C-reactive protein-triglyceride glucose index (CTI) is linked to a higher risk of overactive bladder (OAB). This marker, reflecting inflammation and metabolic status, may help identify individuals at increased risk for OAB.
Area of Science:
- Urology
- Metabolic Syndrome
- Inflammation
Background:
- Overactive bladder (OAB) significantly impacts quality of life and healthcare.
- Chronic inflammation and insulin resistance are independently associated with bladder dysfunction.
- The C-reactive protein-triglyceride glucose index (CTI) combines inflammatory and metabolic markers but its role in OAB is unknown.
Purpose of the Study:
- To investigate the association between the C-reactive protein-triglyceride glucose index (CTI) and overactive bladder (OAB) in a US adult population.
- To evaluate CTI's discriminative ability for OAB risk compared to its components.
Main Methods:
- Cross-sectional analysis of National Health and Nutrition Examination Survey data (2005-2010, 2015-2018).
- OAB defined by self-reported urgency incontinence and nocturia.
- Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were used to assess the association and discriminative performance of CTI.
Main Results:
- Higher CTI levels were significantly associated with increased odds of OAB (OR=1.17 per unit increase).
- The highest CTI quartile showed a 50% increased risk of OAB compared to the lowest quartile.
- CTI demonstrated superior discriminative ability for OAB compared to CRP and TyG (AUC=0.607 vs 0.588 and 0.569).
Conclusions:
- The C-reactive protein-triglyceride glucose index (CTI) is independently associated with overactive bladder (OAB) in US adults.
- CTI may serve as a valuable tool for identifying individuals at elevated risk of OAB, especially younger and socioeconomically disadvantaged groups.
- This composite marker offers a novel approach to assessing OAB risk by integrating inflammatory and metabolic factors.
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