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An Innovative Screening Panel for Preventing Miscarriages-Perspectives, Guidance and Guidelines
1Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, 15-222 Bialystok, Poland.
Antioxidants (Basel, Switzerland)
|May 4, 2026
Summary
This study introduces a novel prenatal screening panel to prevent miscarriage by assessing oxidative stress, toxic metals, NETs, BPA, and microRNAs. This personalized approach aims to improve early pregnancy outcomes and reduce pregnancy loss.
Area of Science:
- Reproductive Medicine
- Immunology
- Toxicology
Background:
- Miscarriage is a common pregnancy complication, necessitating personalized, evidence-based diagnostic and therapeutic approaches.
- Systemic oxidative stress, indicated by an imbalance in oxidative and anti-oxidant mechanisms, is linked to recurrent miscarriage.
- Emerging research highlights the role of environmental factors and specific biological pathways in pregnancy loss.
Purpose of the Study:
- To develop an innovative prenatal screening panel for miscarriage prevention.
- To establish a personalized treatment strategy based on the screening results.
- To integrate novel biomarkers and risk factors into early pregnancy care.
Main Methods:
- Analysis of oxidative stress markers and anti-oxidant mechanisms.
- Monitoring of toxic metal concentrations in early pregnancy.
- Investigation of neutrophil extracellular traps (NETs) and their role in miscarriage pathogenesis.
- Assessment of Bisphenol A (BPA) effects on inflammation and NETs.
- Identification of NO-dependent pathways, NLRP3 inflammasome activation, and microRNA involvement in reproductive failure.
- Development of minimally invasive diagnostic methods for early pregnancy stages.
Main Results:
- Confirmed the link between oxidative stress, toxic metals, and miscarriage.
- Demonstrated the involvement of NETs and BPA in miscarriage pathogenesis and inflammation.
- Identified a NO-dependent pathway involving NLRP3 inflammasome activation, independent of NETs and apoptosis.
- Validated the role of specific microRNAs in reproductive failure and their utility in early, minimally invasive diagnostics.
Conclusions:
- The developed screening panel incorporates key parameters for miscarriage risk assessment.
- This novel approach offers personalized prenatal care focused on miscarriage prevention.
- The findings support the integration of advanced biomarkers for improved early pregnancy management.
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