Related Experiment Video
Updated: May 5, 2026
Isolation, Culture, and Characterization of Primary Schwann Cells, Keratinocytes, and Fibroblasts from Human Foreskin
Published on: March 23, 2022
Ex Vivo Human Foreskin Tissue Circumcision via High-Frequency Electric Welding
Xin Chen1, Cai-Hui Zhu1, Zhong-Zhen Hu1
1College of Intelligent Robotics and Advanced Manufacturing, Fudan University, Shanghai 200433, China.
Background:
Despite the clinical significance of circumcision, traditional suturing is frequently compromised by intraoperative bleeding and lengthy recovery periods. While high-frequency electric welding (HFEW) presents a compelling alternative, its utility in foreskin removal procedures remains unexplored.
Methods:
Employing freshly excised human foreskin tissues, this study simulated the circumcision procedure to benchmark HFEW against standard suturing techniques. Critical performance metrics, encompassing tensile integrity, thermal injury scope, and operative efficiency, were rigorously quantified.
Results:
HFEW demonstrated exceptional time efficiency, averaging 2.01 ± 0.9 min-a 77.02% reduction relative to conventional suturing (p < 0.001). However, mechanical testing revealed disparities in tissue adhesion; the HFEW cohort recorded lower forces for initial tearing (4.42 ± 1.02 N) and complete rupture (6.15 ± 1.65 N) compared to the superior tensile resistance of the suturing group (7.91 ± 3.26 N and 14.22 ± 6.91 N, respectively).
Conclusions:
Although HFEW yields comparatively lower tensile strength, its remarkable operational efficiency positions it as a viable technical innovation for circumcision. These preliminary findings support the pursuit of further in vivo investigations to confirm its clinical applicability.
