Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open and closed-loop control systems01:17

Open and closed-loop control systems

2.0K
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
2.0K
PD Controller: Design01:26

PD Controller: Design

761
In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
761
PI Controller: Design01:24

PI Controller: Design

1.6K
Proportional Integral (PI) controllers are a fundamental component in modern control systems, widely used to enhance performance and mitigate steady-state errors. They are particularly effective in applications such as automatic brightness adjustment on smartphones, where they excel at mitigating steady-state errors for step-function inputs. Unlike PD controllers, which require time-varying errors to function optimally, PI controllers leverage their integral component to address residual...
1.6K
Control Systems: Applications01:25

Control Systems: Applications

1.2K
Electrical engineering plays a pivotal role in our daily lives, with control systems at the heart of many applications, from home appliances to sophisticated space shuttles. Control systems manage and regulate the behavior of devices and processes, ensuring they function safely, correctly, and efficiently.
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep Learning-Based Tracking of Neurovascular Features Toward Semi-Automated Ultrasound-Guided Peripheral Nerve Blocks by Non-Specialists.

Bioengineering (Basel, Switzerland)·2026
Same author

Validation of a Wearable Photoplethysmography-Based Sensor for Compensatory Reserve Measurement Monitoring in Simulated Human Hemorrhage.

Sensors (Basel, Switzerland)·2026
Same author

Experimental evaluation of a real-time implementation of compensatory reserve measurement in a human model of hemorrhagic shock.

Frontiers in bioengineering and biotechnology·2026
Same author

Development of a vasopressor control module for testing hemorrhagic shock resuscitation controllers.

Biomedical engineering online·2026
Same author

Artificial intelligence models for point-of-care ultrasound diagnostics in dogs.

Frontiers in veterinary science·2026
Same author

Smart, automated junctional tourniquets leveraging AI-driven ultrasound guidance.

Scientific reports·2026

Related Experiment Video

Updated: May 5, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.3K

Comparison of Controller Logics for Automating Vasopressor Administration Using a Hardware-in-Loop Test Platform.

Michael D Lopez1, Jonathan Marrero Bermudez1, David Berard1

  • 1Organ Support & Automation Technologies Group, U.S. Army Institute of Surgical Research, Joint Base San Antonio, Fort Sam Houston, TX 78234, USA.

Bioengineering (Basel, Switzerland)
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

Automated vasopressor controllers were developed to precisely manage blood pressure during hemorrhagic shock, improving fluid resuscitation for trauma patients. These systems offer a more stable and effective alternative to manual drug titration.

Keywords:
automationclosed-loopcombat casualty carecontroller developmentfluid resuscitationfuzzy logichardware-in-loophemorrhagic shockvasoactivity

More Related Videos

Interactive and Visualized Online Experimentation System for Engineering Education and Research
08:35

Interactive and Visualized Online Experimentation System for Engineering Education and Research

Published on: November 24, 2021

2.3K
An Isolated Working Heart System for Large Animal Models
09:45

An Isolated Working Heart System for Large Animal Models

Published on: June 11, 2014

32.1K

Related Experiment Videos

Last Updated: May 5, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.3K
Interactive and Visualized Online Experimentation System for Engineering Education and Research
08:35

Interactive and Visualized Online Experimentation System for Engineering Education and Research

Published on: November 24, 2021

2.3K
An Isolated Working Heart System for Large Animal Models
09:45

An Isolated Working Heart System for Large Animal Models

Published on: June 11, 2014

32.1K

Area of Science:

  • Biomedical Engineering
  • Trauma Care
  • Critical Care Medicine

Background:

  • Hemorrhagic shock is a major cause of preventable death in trauma.
  • Fluid resuscitation is standard but can be insufficient or lead to complications in non-responsive patients.
  • Manual vasopressor titration is challenging, especially in mass-casualty events.

Purpose of the Study:

  • To develop and evaluate automated closed-loop vasopressor controllers (PCLCs) for managing hemorrhagic shock.
  • To assess PCLC performance in achieving target mean arterial pressure during simulated hemorrhage.
  • To identify optimal PCLC configurations for precise hemodynamic management.

Main Methods:

  • Ten physiological closed-loop controller (PCLC) configurations were designed and tuned.
  • A hardware-in-loop test platform simulating hemorrhage and fluid-pressure responsiveness was utilized.
  • Controllers were tested across varying starting pressure scenarios to evaluate performance metrics.

Main Results:

  • The test platform successfully differentiated the performance of various PCLC designs.
  • Some PCLC configurations overshot or failed to reach the target mean arterial pressure.
  • High-performing PCLCs demonstrated rapid and consistent achievement and maintenance of target blood pressure.

Conclusions:

  • Automated closed-loop vasopressor controllers show promise as an adjuvant to fluid resuscitation in hemorrhagic shock.
  • Selected PCLC configurations offer precise hemodynamic management, potentially improving outcomes in trauma patients.
  • Further evaluation of leading PCLCs is needed to develop a robust controller for clinical application.