Related Experiment Video

Updated: May 5, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

803

Prognostic Role of High-Sensitivity C-Reactive Protein/Albumin Ratio in Heart Failure Patients

Domenico Martire1, Giuseppe Armentaro2, Giandomenico Severini2

  • 1Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.

Biomedicines
|May 4, 2026
PubMed

Insights

The high-sensitivity C-reactive protein to Serum albumin (hs-CRP/SA) ratio effectively predicts major adverse cardiovascular events (MACEs) in chronic heart failure (CHF) patients. A higher hs-CRP/SA ratio indicates significantly increased cardiovascular risk.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Risk Stratification

Background:

  • Chronic heart failure (CHF) poses a significant cardiovascular risk.
  • Identifying reliable biomarkers for risk stratification in CHF is crucial.
  • The hs-CRP/SA ratio is an emerging biomarker for cardiovascular risk.

Purpose of the Study:

  • To evaluate the long-term prognostic value of the hs-CRP/SA ratio.
  • To assess the risk of major adverse cardiovascular events (MACEs) in outpatients with CHF.
  • To determine if the hs-CRP/SA ratio can stratify cardiovascular risk in CHF patients.

Main Methods:

  • Retrospective observational study of 500 outpatients with CHF.
  • Stratification into two groups based on the median hs-CRP/SA ratio (<1.19 and ≥1.19).
  • Median follow-up of 5.2 years to track MACE incidence.

Main Results:

  • Patients with hs-CRP/SA ≥ 1.19 experienced a MACE incidence of 5.9 events/100 patient-years versus 1.2 events/100 patient-years for hs-CRP/SA < 1.19 (p < 0.001).
  • Multivariate analysis revealed hs-CRP/SA ≥ 1.19 was associated with a 6.5-fold increased risk of MACEs (HR 6.513, p < 0.001).
  • The hs-CRP/SA ratio demonstrated significant predictive power for MACEs.

Conclusions:

  • The hs-CRP/SA ratio is a potent prognostic marker in CHF.
  • Elevated hs-CRP/SA ratios are significantly associated with increased MACE risk.
  • This ratio aids in stratifying cardiovascular risk in CHF outpatients.

Keywords:
MACEheart failurehs-CRP/serum albumin ratioinflammation biomarkers

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