Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

1.6K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.6K
Surface Membrane Barriers01:18

Surface Membrane Barriers

3.0K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.0K
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

1.0K
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
1.0K
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

55
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
55
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

9.6K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.6K
Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

2.6K
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-Criteria Antiphospholipid Antibodies in Women with Recurrent Pregnancy Loss.

Biomedicines·2026
Same author

Epidemiology, Risk Factors, Diagnosis, and Comorbidities of Endometriosis: An Umbrella Review.

Journal of clinical medicine·2026
Same author

Distribution of Thrombophilia-Related Genetic Polymorphisms in Women with Reproductive Disorders.

Biomedicines·2026
Same author

Blood Immunophenotyping in Prediction of Gestational Hypertensive Conditions.

Biomedicines·2025
Same author

Multidimensional Visualization and AI-Driven Prediction Using Clinical and Biochemical Biomarkers in Premature Cardiovascular Aging.

Biomedicines·2025
Same author

Exploring the Associations Between <i>CHRNA5</i> and <i>IREB2</i> Gene Polymorphisms and COPD in the Kazakhstan Population.

Biomedicines·2025

Related Experiment Video

Updated: May 5, 2026

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution
11:39

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution

Published on: September 21, 2012

47.9K

Airway Mucosal Defense: Mucins, Innate Immunity, and Contemporary Mucoactive Strategies.

Almira Akparova1, Gaukhar Kurmanova1, Gulzhakhan Omarova1

  • 1Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.

Biomedicines
|May 4, 2026
PubMed
Summary

Mucins are vital for respiratory innate immunity, acting as a barrier and immune regulator. Dysfunctional mucins cause airway diseases, necessitating targeted mucoactive therapies for better patient outcomes.

Keywords:
MUC5ACMUC5Bhomeostasisimmunological defenseinfectionsinflammationinnate immunitymicrobiotamucinsmucoactive therapymucociliary clearancemucous membranespathogens

More Related Videos

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins
09:24

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins

Published on: June 14, 2016

25.8K
Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging
05:10

Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging

Published on: September 12, 2025

679

Related Experiment Videos

Last Updated: May 5, 2026

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution
11:39

Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution

Published on: September 21, 2012

47.9K
Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins
09:24

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins

Published on: June 14, 2016

25.8K
Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging
05:10

Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging

Published on: September 12, 2025

679

Area of Science:

  • * Biomedical Science
  • * Respiratory Medicine
  • * Immunology

Background:

  • * Mucins form the structural basis of mucus, crucial for innate immunity at mucosal surfaces, especially the respiratory tract.
  • * They perform mechanical barrier functions, pathogen trapping, mucociliary clearance regulation, and modulate inflammation.
  • * Mucin dysregulation is linked to mucus hypersecretion and impaired airway clearance in diseases like asthma, COPD, and cystic fibrosis.

Purpose of the Study:

  • * To review current knowledge on mucin biology, focusing on gel-forming mucins MUC5AC and MUC5B.
  • * To explore the role of mucins in mechanical protection, host-pathogen interactions, and innate immune responses.
  • * To examine mucoactive therapeutic strategies for restoring mucus barrier function in airway diseases.

Main Methods:

  • * Comprehensive literature review of mucin biology and mucoactive therapies.
  • * Analysis of mucin structure, biosynthesis, classification, and regulation.
  • * Evaluation of established and emerging therapeutic targets and non-pharmacological approaches.

Main Results:

  • * Mucins are dynamic regulators of innate immunity, influencing epithelial homeostasis and airway barrier integrity.
  • * Mucin function is intricately linked with immune cells and microbial communities.
  • * Various mucoactive agents and molecular targets show potential for treating chronic airway diseases.

Conclusions:

  • * Mucins are key players in innate immunity and airway health.
  • * Understanding mucin biology is crucial for developing effective treatments for chronic inflammatory airway diseases.
  • * Personalized, mechanism-based mucoactive therapies are needed to improve patient outcomes.