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Human-in-the-Loop Artificial Intelligence: A Systematic Review of Concepts, Methods, and Applications.

Konstantinos Lazaros1, Aristidis G Vrahatis1, Sotiris Kotsiantis2

  • 1Department of Informatics, Ionian University, 49100 Corfu, Greece.

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|May 4, 2026
PubMed
Summary
This summary is machine-generated.

Human-in-the-loop (HITL) AI integrates human judgment into artificial intelligence systems for high-stakes applications. This survey reviews HITL methods, applications, and challenges, proposing a framework for effective human-AI collaboration.

Keywords:
active learningartificial intelligenceexplainable AIhuman oversighthuman-in-the-loophuman–AI collaborationmachine learningreinforcement learning

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Area of Science:

  • Artificial Intelligence
  • Human-Computer Interaction
  • Machine Learning

Background:

  • High-stakes applications necessitate human oversight in AI systems where full automation is insufficient.
  • Human-in-the-Loop (HITL) AI combines machine learning with human feedback and decision-making.
  • Existing research lacks a unified taxonomy and comprehensive review of HITL approaches.

Purpose of the Study:

  • To systematically review Human-in-the-Loop AI methodologies, theoretical underpinnings, and applications.
  • To propose a novel taxonomy for categorizing HITL systems.
  • To identify challenges and outline future research directions for effective human-AI collaboration.

Main Methods:

  • Systematic literature review of HITL AI.
  • Development of a unified taxonomy based on loop placement, interaction granularity, and temporal characteristics.
  • Synthesis of findings across diverse domains including healthcare, autonomous systems, and cybersecurity.

Main Results:

  • Categorization of HITL systems using the proposed taxonomy.
  • Identification of key challenges such as scalability, cognitive load, and trust calibration.
  • Synthesis of domain-specific applications highlighting the essential role of human oversight.

Conclusions:

  • HITL AI is crucial for high-risk domains requiring human judgment.
  • A structured approach to HITL system design is needed.
  • Further research should focus on addressing practical deployment challenges and developing robust human-AI collaboration frameworks.